Progressive MS is one of the very few conditions where TUDCA has been through a double-blind, placebo-controlled human trial. Here is what that trial was designed to answer, what it found, and the large question it deliberately left open.
TUDCA has been given to human patients in registered amyloidosis trials, paired with prescription doxycycline. This is the clearest case of TUDCA’s chaperone activity being tested in people, and also the clearest case of why it is not a supplement protocol.
Twenty days of TUDCA increased muscle mass and restored fibre size in 18-month-old mice. Combined with the human insulin-sensitivity trial, it is the most interesting muscle evidence TUDCA has. Here is how far it goes.
A bile acid cut infarct size roughly in half in a rat stroke model. That was 2002. Two decades later there is still no human stroke trial. Here is what the research showed and why the gap matters.
Endoplasmic reticulum stress drives cardiac hypertrophy and fibrosis, and TUDCA reduced both in a mouse pressure-overload model. What that animal evidence does and does not say about human heart health.
TUDCA reached a human Alzheimer’s trial as half of a combination drug. The clinical endpoints missed. The biomarker results were more interesting. An honest read of where this research stands.
A small open-label trial gave patients with active ulcerative colitis oral TUDCA for six weeks and measured endoscopic and histologic change. What it found, and the four reasons the result needs a controlled trial before it means much.
PBC is the one condition where TUDCA has been tested head-to-head against standard-of-care UDCA in a randomized trial. Here is what those human studies found, and why that does not make TUDCA a substitute for prescription treatment.
Bloating, greasy stools, discomfort after fatty meals – is this a bile acid deficiency, and does TUDCA help? An honest look at what the research actually covers.
TUDCA is well studied for inherited retinal degeneration. Does the evidence support it for age-related macular degeneration specifically? An honest look at the RPE research.
TUDCA and kidney function: what the animal research on acute kidney injury, diabetic nephropathy, and ER stress shows, and why human trials don’t exist yet.
What the research on TUDCA and bile acid physiology actually shows for people managing gallbladder disease or recovering after cholecystectomy.